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PUBLICATIONS (PUBLISHED, IN PRESS OR ACCEPTED)

 

Simoes ML and Dimopoulos G. (2015) A mosquito mediator of parasite-induced immune priming. Trends Parasitol. pii: S1471-4922(15)00168-3.

 

1.      Zhang G, Niu G, Franca CM, Dong Y, Wang X, Butler NS, Dimopoulos G, Li J. (2015) Anopheles Midgut FREP1 Mediates Plasmodium Invasion. J Biol Chem. 290(27):16490-501.

 

Sandiford SL, Dong Y, Pike A, Blumberg BJ, Bahia AC and Dimopoulos G (2015) Cytoplasmic actin is an extracellular insect immune factor which is secreted upon immune challenge and mediates phagocytosis and direct killing of bacteria, and is a Plasmodium antagonist. PLoS Pathogens 11(2):e1004631.

 

Dennison NJ, BenMarzouk-Hidalgo, OJ and Dimopoulos G (2014) MicroRNA-regulation of Anopheles gambiae immunity to Plasmodium falciparum infection and midgut microbiota. Dev Comp Immunol. 49(1):170-8.

 

Ramirez JL, Short SM, Bahia AC, Saraiva RG, Dongn Y, Kang S, Tripathi T, Mlambo G and Dimopoulos G (2014) Chromobacterium Csp_P reduces malaria and dengue infection in vector mosquitoes and has entomopathogenic and in vitro anti-pathogen activities. PLoS Pathogens 10(10):e1004398.

 

Sanders, N, Sullivan D, Mlambo G, Dimopoulos G, Tripathi A (2014) Gametocytocidal screen identifies novel chemical classes with Plasmodium falciparum transmission blocking activity. PLoS One, 9(8):e105817.

 

Kang S, Shields AR, Jupatanakul N and Dimopoulos G (2014) Suppressing dengue-2 infection by chemical inhibition of Aedes aegypti host factors. PLoS NTD, 7;8(8):e3084.

 

Pike A, Vadlamani A, Sandiford SL, Gacita A, Dimopoulos G (2014) Characterization of the Rel2-regulated transcriptome and proteome of Anopheles stephensi identifies new anti-Plasmodium factors. Insect Biochem Mol Biol. 52C:82-93.

 

Bahia AC, Dong Y, Blumberg BJ, Mlambo G, Tripathi A, BenMarzouk-Hidalgo OJ, Chandra R, and Dimopoulos G (2014) Exploring Anopheles gut bacteria for Plasmodium blocking activity. Environmental Microbiology, 5. doi: 10.1111/1462-2920.12381.

 

Jupatanakul N, Sim S, and Dimopoulos G (2014) Aedes aegypti ML and Niemann-Pick type C family members are agonists of dengue virus infection. Dev Comp Immunol. 43(1):1-9.

 

Blumberg JB, Trop S, Das S, Dimopoulos G (2013) Bacteria- and IMD pathway-independent immune defenses against Plasmodium falciparum in Anopheles gambiae. PLoS One, 10.1371/journal.pone.0072130.

 

Sim S, Jupatanakul N, Ramirez JL, Kang, S, Romero-Vivas CM, Mohammed H and Dimopoulos G (2013) Transcriptomic profiling of diverse Aedes aegypti strains reveals increased basal-level immune activation in dengue virus-refractory populations and identifies novel virus-vector molecular interactions. PLoS NTD, 7(7):e2295.

 

Bian G, Joshi D, Dong Y, Lu P, Zhou G, Pan X, Xu Y, Dimopoulos G, Xi Z (2013) Wolbachia Invades Anopheles stephensi Populations and Induces Refractoriness to Plasmodium Infection. Science, 340(6133):748-751.

 

Clayton AM, Cirimotich C, Dong, Y and Dimopoulos G (2013) Caudal is a negative regulator of the Anopheles Imd pathway that controls resistance to Plasmodium falciparum infection. Dev Comp Immunol. 39(4):323-332.

 

Dong Y, Cirimotich C, Pike A, Chandra R and Dimopoulos G (2012) Anopheles NF-?B -regulated splicing factors direct pathogen-specific repertoires of the hypervariable pattern recognition receptor AgDscam. Cell Host & Microbe 12, 521–530.

 

Chen Y, Dong Y, Sandiford S and Dimopoulos G Transcriptional mediators Kto and Skd are involved in the regulation of the IMD pathway and anti-Plasmodium defense in Anopheles gambiae. (2012) PLoS ONE;7(9):e45580.

 

Garver LS, Bahia AN, Das S, Souza-Neto J, Shiao J, Dong Y and Dimopoulos G (2012) Anopheles Imd pathway factors and effectors in infection intensity-dependent anti-Plasmodium action. PLoS Pathogens. PLoS Pathogens 8(6): e1002737.

 

Sim S, Ramirez JL and Dimopoulos G (2012) Reciprocal interactions between the dengue virus and Aedes aegypti salivary gland and chemosensory apparatus influences vector competence. PLoS Pathogens. 8(3):e1002631.

 

Ramirez LJ, Souza-Neto J, Cosme RT, Rovira J, Ortiz A, Pascale JM and Dimopoulos G (2012) Reciprocal Tripartite Interactions between the Aedes aegypti Midgut Microbiota, Innate Immune System and Dengue Virus Influences Vector Competence. PLoS Neglected Trop Dis. 6(3):e1561.

 

Gomulski L, Dimopoulos G, Xi Z, Gabrieli P, Scolari P, Siciliano P, Malacrida AR, Gasperi G (2012) Changes in gene expression related to maturation and mating in male and female medfly, Ceratitis capitata. PLoS One. 7(1):e30857.

 

Dong Y, Morton JC Jr, Ramirez JL, Souza-Neto J and Dimopoulos G (2012) The entomopathogenic fungus Beauveria bassiana activate Toll and JAK-STAT pathway controlled effector genes and anti-dengue activity in Aedes aegypti. Insect Biochem. & Mol. Biol. 42(2):126-32.

 

Dong Y, Das S, Cirimotich CM, Souza-Neto J, McLean K and Dimopoulos G (2011) Engineered Anopheles immunity to Plasmodium infection. PLoS Pathogens 7(12): e1002458.

 

Zou Z, Souza-Neto JA, Xi Z, Kokoza V, Shin SW, Dimopoulos G, and Raikhel AS (2011) Transcriptome analysis of Aedes aegypti transgenic mosquitoes with altered immunity. PLoS Pathogens. 7(11):e1002394.

 

Cirimotich CM, Dong Y, Clayton AM, Sandiford SL, Souza-Neto JA, Mulenga M, and Dimopoulos G (2011) Natural microbe-mediated refractoriness to Plasmodium infection in Anopheles gambiae. Science 332: 855-858.

 

Das S., Radtke A., Choi YJ., Mendes A., Valenzuela J. and Dimopoulos G (2010) The salivary gland transcriptome of Anopheles gambiae and its implication in blood feeding. BMC Genomics 11:566.

 

Bartholomay LC, Waterhouse RM, Mayhew GF, Campbell CL, Michel K, Zou Z, Ramirez JL, Das S, Alvarez K, Arensburger P, Bryant P, Chapman SB, Dong Y, Erickson SM, Karunaratne SHPP, Kokoza V, Kodira CD, Pignatelli P, Shin SW, Vanlandingham DL, Atkinson PW, Birren B, Christophides GK, Clem RJ, Hemingway J, Higgs S, Megy K, Ranson H, Zdobnov EM, Raikhel AS, Christensen BM, Dimopoulos G, and Muskavitch MAT (2010) Pathogenomics of Culex quinquefasciatus and meta-analysis of infection responses to diverse Pathogens. Science 330: 88-90.

 

Arensburger P, Megy K, Waterhouse R, Abrudan J, Amedeo P, Antelo B, Bartholomay L, Bidwell S, Caler E, Camara F, Campbell CL, Campbell KS, Casola C, Castro MT, Chandramouliswaran I, Chapman SB, Christley S, Costas J, Eisenstadt E, Feschotte C, Fraser-Liggett C, Guigo R, Haas B, Hammond M, Hansson BS, Hemingway J, Hill SR, Howarth C, Ignell R, Kennedy RC, Kodira CD, Lobo NF, Mao C, Mayhew G, Michel K, Mori A, Liu N, Naveira H, Nene V, Nguyen N, Pearson MD, Pritham EJ, Puiu D, Qi Y, Ranson H, Ribeiro JMC, Robertson HM, Severson DW, Shumway M, Stanke M, Strausberg MR, Sun C, Sutton G, Tu Z, Tubio JMC, Unger MF, Vanlandingham VL, Vilella AJ, White O, White JR, Wondji CS, Wortman J, Zdobnov EM, Birren B, Christensen BM, Collins FH, Cornel A, Dimopoulos G, Hannick LI, Higgs S, Lanzaro G, Lee N, Muskavitch MAT, Raikhel A, Atkinson P (2010) Sequencing of Culex quinquefasciatus establishes a platform for  mosquito comparative genomics. Science 330: 86-88.

 

Aguilar R, Simard F, Kamdem C, Shields T, Glass GE, Garver LS, and Dimopoulos G (2010) Genome-wide analysis of transcriptomic divergence between laboratory colony and field Anopheles gambiae mosquitoes of the M and S molecular forms. Insect Mol Biol. 19(5):695-705. (Journal Impact Factor: ~ 2.7)

 

Sim S and Dimopoulso G (2010) Dengue Virus Inhibits Immune Responses in Aedes aegypti Cells. PLoS One, 18;5(5):e10678.

 

Ramirez JL and Dimopoulos G (2010) The Toll immune signaling pathway control conserved anti-dengue defenses across diverse Ae. aegypti strains and against multiple dengue virus serotypes. Dev Comp Immunol. 34: 625-629.

 

Mair GR, Lasonder E, Garver LS, Franke-Fayard B, Carret CK, Wiegant J, Dirks R, Dimopoulos G., Janse CJ, Waters AP. (2010) An evolutionarily ancient P body controls zygote development in the protozoan parasite Plasmodium. PLoS Pathogens 12;6: e1000767.

 

Souza-Neto JA, Sim S, and Dimopoulos G (2009) Evolutionary conserved function of the JAK-STAT pathway in anti-dengue defense. Proc. Natl. Acad. Sci. USA. 106:17841- 6.

 

Dong Y., Manfredini F. and Dimopoulos G (2009) Implication of the Mosquito Midgut  Microbiota in the Defense Against Malaria Parasites. PLoS Pathogens, 5(5), e1000423.

 

Erickson SA, Xi Z, Mayhew GF, Ramirez JL, Aliota MT, Christensen BM, Dimopoulos G (2009) Mosquito Infection Responses to Developing Filarial Worms. PLoS Trop. Negl. Dis. 3(10):e529.

 

Baton LA, Robertson A, Warr E, Strand MR, and Dimopoulos G (2009) Genome-wide transcriptomic profiling of Anopheles gambiae hemocytes reveals pathogen-specific signatures upon bacterial challenge and Plasmodium berghei infection. BMC Genomics, 10(1):257.

 

Sessions OM,  Barrows N,  Souza-Neto JA, Robinson TJ, Hershey CL, Rodgers MA, Ramirez JL, Dimopoulos G,  Yang PL,  Pearson JL,  and Garcia-Blanco MA. (2009) Discovery of Dengue Virus Host Factors in Insects and Humans. Nature, 458(7241):1047-1050.

 

Dong, Y. and Dimopoulos, G (2009) Anopheles fibrinogen –related proteins provide expanded pattern recognition capacity against bacteria and malaria parasites. Journal of Biological Chemistry, Feb 4. Epub ahead of print.

 

Garver LS., Dong Y., and Dimopoulos G (2009) Caspar control resistant to Plasmodium falciparum in diverse Anopheline species. PLoS Pathogens, Mar;5(3):e1000335.

 

Das S., and Dimopoulos G (2008) Molecular analysis of photic inhibition of blood-feeding in Anopheles gambiae. BMC Physiology 16;8(1):23.

 

Abrantes A., Dimopoulos G., Grosso AR., do Rosário VE. and Silveira H. (2008) Chloroquine mediated modulation of Anopheles gambiae gene expression. PLoS ONE 2;3(7).

 

Xi Z., Ramirez JL., Dimopoulos G (2008) The Aedes aegypti Toll pathway controls dengue virus infection. PLoS Pathog.4(7).

 

Gomulski LM., Dimopoulos G., Xi Z., Soares MB., Bonaldo MF., Malacrida AR., Gasperi G. (2008) Gene discovery in an invasive tephritid model pest species, the Mediterranean fruit fly, Ceratitis capitata. BMC Genomics 2008, 9:248.

 

Warr, E., Das, S., Dong, Y., and Dimopoulos, G (2008) The Gram-Negative Bacteria-Binding Protein gene family: Its role in the innate immune system of Anopheles gambiae and in anti-Plasmodium defense. Insect Mol. Biol., 17:39-51.

 

Garver, LS, Xi, Z and Dimopoulos, G (2008) Immunoglobulin superfamily members play an important role in the mosquito immune system, Dev. & Comp. Immunol. 32:519-31.

 

Aguilar, R., Das, S., Dong, Y. and Dimopoulos, G (2007) Continuous exposure to Plasmodium results in decreased susceptibility and transcriptomic divergence of the Anopheles gambiae immune system. BMC Genomics, 8:451.

 

Waterhouse, RM, Kriventseva, EV, Meister, S, Xi, Z, Alvarez, KV, Bartholomay, LC, Barillas-Mury, C, Bian, G, Blandin, S, Christensen, BM, Dong, Y, Jiang, H, Kanost, MR, Koutsos, AC, Levashina, EA, Li, J, Ligoxygakis, P, MacCallum, RM, Mayhew, GF, Mendes, A, Michel, K, Osta, MA, Paskewitz, S, Shin SW, Vlachou, D, Wang, L, Wei, W, Zheng, L, Zou, Z, Severson, DW, Raikhel, AS, Kafatos, FC, Dimopoulos, G, Zdobnov, EM, Christophides, GK (2007) Evolutionary dynamics of immune-related genes and pathways in disease vector mosquitoes. Science, 316:1738-1743.

 

Nene, V, Wortman, JR, Lawson, D, Haas, B, Kodira, C, Tu, ZJ, Loftus, B, Xi, Z, Megy, K, Grabherr, M, Ren, Q, Zdobnov, EM, Lobo, NF, Campbell, KS, Brown, SE, Bonaldo, MF, Zhu, J, Sinkins, SP, Hogenkamp, DG, Amedo, P, Arsenburger, P, Atkinson, PW, Bidwell, S, Biedler, J, Birney, E, Bruggner, RV, Costas, J, Coy, MR, Crabtree, J, Crawford, M, Debruyn, B, Decaprio, D, Eiglmeier, K, Eisenstadt, E, El-Dorry, H, Gelbart, WM, Gomes, SL, Hammond, M, Hannick, LI, Hogan, JR, Holmes, MH, Jaffe, D, Johnston, SJ, Kennedy, RC, Koo H, Kravitz, S, Kriventseva, EV, Kulp, D, Labutti, K, Lee, E, Li S, Lovin, DD, Mao, C, Mauceli, E, Menck, CF, Miller, JR, Montgomery, P, Mori, A, Nascimento, AL, Naveira, HF, Nusbaum, C, O'leary, SB, Orvis, J, Pertea, M, Quesneville, H, Reidenbach, KR, Rogers, YH, Roth, CW, Schneider, JR, Schatz, M, Shumway, M, Stanke, M, Stinson, EO, Tubio, JM, Vanzee, JP, Verjovski-Almeida, S, Werner, D, White, O, Wyder, S, Zeng, Q, Zhao, Q, Zhao, Y, Hill, CA, Raikhel, AS, Soares, MB, Knudson, DL, Lee ,NH, Galagan, J, Salzberg, SL, Paulsen, IT, Dimopoulos, G, Collins, FH, Bruce, B, Fraser-Liggett, CM, Severson, DW. (2007) Genome sequence of Aedes aegypti, a major arbovirus vector. Science, 316:1718-1723.

 

Warr, E, Aguilar, R, Dong, Y. and Dimopoulos, G (2007) Transcriptome and proteome dissection of the Anopheles gambiae midgut. BMC Genomics, 8:37.

 

Warr, E, Lambrechts, L, Bourgouin C, Koella, J, and Dimopoulos, G (2006) Melanization of Sephadex Beads in Anopheles gambiae is controlled by anti-Plasmodium immune factors. Insect Biochemistry and Molecular Biology, 36:769-778.

 

Mair G, Braks J.A.M, Garver L, Wiegant J.K.A.G, Hall Dirks, R.W, Khan S.M, Dimopoulos, G, Janse C.J, Waters A.P. (2006) Regulation of sexual development of Plasmodium by translational repression. Science, 313(5787):667-669.

 

Dong Y, Taylor H.E, and Dimopoulos, G (2006) AgDscam, a hyper variable immunoglobulin domain containing receptor of the Anopheles gambiae innate immune system. PLoS Biology 4: e229.

 

Dong Y, Aguilar R, Xi Z, Warr E, Mongin E, and Dimopoulos, G (2006) Anopheles gambiae immune responses to human and rodent Plasmodium parasite species. PLoS Pathogens 6: 1-13.

 

Heard NA, Holmes CC, Stephens DA, Hand DJ and Dimopoulos, G (2005) Bayesian Co-clustering of Anopheles Gene Expression Time Series: A Study of Immune Defense Response To Multiple Experimental Challenges. Proc Natl Acad Sci U S A 102:16939-16944.

 

Xu, XJ, Dong, Y, Abraham, EG, Kocan, A, Srinivasan, P, Sinden,  RE, Ribeiro, JMC, Jacobs-Lorena, M, Kafatos, FC, and Dimopoulos, G. (2005) Transcriptome analysis of Anopheles stephensi-Plasmodium berghei interactions. Mol Biochem Parasitol. 142:76-87.

 

Both, M, Eckert, SE, Csukai, M, Dimopoulos, G, Spanu PD. (2005) Transcript profiles of Blumeria graminis development during infection reveal a cluster of genes that are potential virulence determinants. Molecular Plant-Microbe Interactions. 18(2):125-133.

 

Aguilar, R, Jedlicka, AE, Mintz, M, Mahairaki, V, Scott AL, and Dimopoulos, G (2005) Global gene expression analysis of Anopheles gambiae responses to microbial challenge. Insect Biochem Mol Biol. ;35:709-719.

 

Abraham EG, Islam S, Srinivasan P, Ghosh AK, Valenzuela JG, Ribeiro LMC, Kafatos FC, Dimopoulos, G and Jacobs-Lorena M. (2004) Analysis of the Plasmodium and Anopheles transcriptional repertoire during ookinete development and midgut invasion.  J Biol Chem. 279: 5573-5580.

 

Srinivasan P, Abraham EG, Ghosh AK, Valenzuela J, Ribeiro JMC, Dimopoulos, G, Kafatos FC, Adams JH, Fujioka J and Jacobs-Lorena M. (2004) Analysis of The Plasmodium and Anopheles transcriptomes during oocyst differentiation. J Biol Chem. 279: 5581-5587.

 

Wu MH, Dimopoulos, G, Mantalaris A, Varley J. (2003) The effect of hyperosmotic pressure on the antibody production and gene expression of GS-NS0 cell line. Biotechnol Appl Biochem. Nov 13.

 

Kumar S, Christophides GK, Cantera R, Charles B, Soon HY, Meister P, Dimopoulos, G, Kafatos FC, Barillas-Mury C. (2003) The role of Reactive Oxygen Species (ROS) on Plasmodium melanotic encapsulation in Anophele gambiae.  Proc. Natl. Acad. Sci. USA. 100: 14139- 14144.

 

 

REVIEW ARTICLES

 

Jupatanakul N, Sim S, Dimopoulos G. (2014) The insect microbiome modulates vector competence for arboviruses. Viruses, Accepted for publication.

 

Sim S., Jupatanakul N., Dimopoulos G. (2014) Mosquito Immunity against Arboviruses. Viruses, Accepted for publication.

 

Dennison NJ, Jupatanakul N, Dimopoulos G. (2014) The mosquito microbiota influences vector competence for human pathogens. Curr. Opin. Insect Sci. 3, 6–13.

 

Clayton AM, Dong Y and Dimopoulos G (2014) The Anopheles innate immune system in the defense against malaria infection. J Innate Immunity. 6(2):169-81.

 

Cirimotich CM, Ramirez JL and Dimopoulos G (2011) Native microbiota shape insect vector competence for human pathogens. Cell Host & Microbe. 10(4):307-10.

 

Cirimotich CM, Dong Y, Garver LS, Sim S, Dimopoulos G. (2009) Mosquito immune defenses against Plasmodium infection. Dev Comp Immunol. 34(4):387-95.

 

Sim S, Ramirez JL, and Dimopoulos G. (2009) Molecular discrimination of mosquito vectors and their pathogens. Expert Review of Molecular Diagnostics. 9(7):757-65.

 

Ramirez JL., Garver L., and Dimopoulos G. (2008) Challenges and Approaches for Mosquito Targeted Malaria Control. Curr. Mol. Medicine. 9(2):116-30.

 

Baton L, Garver L, Xi Z and Dimopoulos G. (2008) Functional genomics studies on the innate immunity of disease vectors. Insect Science, 15:15-27.

 

Dimopoulos G. (2007) Building a better mosquito: identifying the genes enabling malaria and dengue fever resistance in A. gambiae and A. aegypti mosquitoes. J Vis Exp. (5):233.

 

Baton, L, Garver, L.S, Xi, Z, and Dimopoulos, G. (2007) Functional genomics studies on the innate immunity of disease vectors. Insect Science. 15:15-27.

 

Baton, L, Dong, Y, Li, J. and Dimopoulos, G. (2006) Variation in mosquito immunity to Plasmodium. Proceedings of the 11th International Congress of Parasitology.

 

Aguilar R, Dong Y, Warr E and Dimopoulos, G. (2005) Anopheles infection responses: laboratory models versus field malaria transmission systems. Acta Tropica 95(3):285-291.

 

Dimopoulos, G. (2003) Insect immunity and its implication in mosquito-malaria interactions.

Microreview Cell Microbiol.5: 3-14.

 

 

BOOKS & BOOK CHAPTERS

 

Sim S, Cirimotich CM, Ramirez JL, Souza-Neto JA, Dimopoulos G (2012) Dengue Virus-Mosquito Interactions and Molecular Methods of Vector Control. In Dengue and Dengue Hemorrhagic Fever. 2nd Edition. Edited by Duane J Gubler, Jeremy Farrar, Eng Ooi and Subhash Vasudevan. CABI. Under editorial processing.

 

Pike AD, Cirimotich CM and Dimopoulos G (2012) Mosquito Fitness Impact of Transgenic Immune Deployment. In Ecology of Vector Borne Disease Control, 3rd Edition. Edited by Sander Koenraadt and Willem Takken. Wageningen Academic Publishers.

 

Baton, L., Warr, E., Hoffman S. and Dimopoulos, G. (2007) Programmed cell death during malaria parasite infection of the vertebrate host and mosquito vector. In Programmed Cell Death in Protozoa. Edited by José Manuel Pérez Martin. Landes Bioscience, Springer.

 

Dimopoulos G (2008) Paperless Joy: Paperless Business & Lifestyle Design with Information & Communication Technology. 1st Edition, Digital Life Artist Inc.

 

Garver, L.S., Baton, L., and Dimopoulos, G. (2007) Mosquito Immunity to the Malaria Parasite. In Insect Immunology. Edited by Nancy Beckage. Elsevier.


 
Department of Molecular Microbiology & Immunoogy
Johns Hopkins Malaria Research Institute

Bloomberg School of Public Health
Johns Hopkins University
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